Which method of IV contrast agent administration provides the greatest overall plasma iodine concentration?

The bolus technique is the method of intravenous contrast agent administration that provides the greatest overall plasma iodine concentration. This technique involves delivering a rapid and concentrated dose of the contrast agent into the bloodstream. The quick infusion leads to a significant peak in plasma iodine levels as the contrast agent rapidly distributes throughout the vascular system, enhancing the visibility of structures during imaging.

This high peak concentration is particularly beneficial in computed tomography because it maximizes the contrast between different tissues, allowing for more effective differentiation of structures and pathological findings. The bolus method is often preferred for various imaging studies because it allows for optimal timing with the imaging protocols and maximizes image quality.

In contrast, gravity infusion delivers the contrast agent more slowly, which may not achieve the same peak iodine concentration in a short period and can result in a more dispersed concentration over time. Continuous drip can maintain a steady state of iodine levels but typically does not reach the high peak seen with bolus injection. Intermittent infusion, while it allows for some variability in delivery, also lacks the rapid initial rise in iodine concentration that is critical for many imaging applications.